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刘文静个人简介

发文单位: 发文时间:2018-03-22

刘文静,女,博士,副研究员。2014年毕业于香港中文大学并获得博士学位。博士期间主要从事肾脏损伤修复机制研究。毕业后继续在夏银教授实验室从事博士后研究。2015年完成博士后课题后应聘至威尼斯官方入口—welcomec工作。现主要从事肾脏疾病病理机制的研究,主持国家自然科学基金、省基金项目3项,参加国家基金、省级项目3项。

代表论文:

(1) Liu WJ#, Chen BB#, et al. RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proc Natl Acad Sci U S A, 2018, 115: 1475-1484.

(2) Chen F#, Hu Q#, ......, Liu WJ*. Follistatin-like protein 1 increases transepithelial resistance in kidney epithelial cells through Akt signaling. Mol Med Rep, 2017, 16(4): 4341-4347.

(3) Chen XJ#, Liu WJ#, et al. Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats., Sci Rep., 2017, 7:41144. doi: 10.1038/srep41144.

(4) Liu WJet al. Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells., J Biol Chem, 2013, 288(44): 31528-31539.

(5) Liu WJ#Ma LQ#, et al. Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3.Am J Pathol, 2011, 178(4):1489-1499.

(6) Zou T#Liu WJ#et al. TRB3 mediates homocysteine-induced inhibition of endothelial cell proliferation.J Cell Physiol2011226(11): 2782-2789.

(7) Huang HH ……, Liu WJ, et al. Lethal (3) malignant brain tumor like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney Int, 2017.

(8) Meng CLLiu WJet al. Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice.Biol Reprod2016944: 78.

(9) Zhao YS……Liu WJet al. IL-1beta inhibits beta-Klotho expression and FGF19 signaling in hepatocytes.Am J Physiol Endocrinol Metab20163104):E289-E300.

(10) Wu XG……Liu WJet al. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression.Blood20141248):1335-1343# co-first author, * corresponding author.